Abstract
THIS communication reports our investigation of the action of 7-hydroxymethyl-12-methylbenz(a)anthracene (7-OHM-MBA) on the adrenal glands of normal rats and of rats treated by methods that protect the adrenal glands against 7,12-dimethylbenz(a)anthracene (9,10-dimethyl-1,2-benzanthracene, or DMBA)1,2.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Currie, A. R., Helfenstein, J. E., and Young, S., Lancet, ii, 1199 (1962).
Wheatley, D. N., Kernohan, I. R., and Currie, A. R., Nature, 211, 387 (1966).
Huggins, C., and Morii, S., J. Exp. Med., 114, 741 (1961).
Wheatley, D. N., Gerrard, M. E., and Currie, A. R. (in preparation).
Boyland, E., and Sims, P., Biochem. J., 95, 780 (1965).
Boyland, E., Sims, P., and Huggins, C., Nature, 207, 816 (1965).
Dao, T. L., and Tanaka, Y., Proc. Soc. Exp. Biol. N.Y., 113, 78 (1963).
Chart, J. J., Sheppard, H., Allen, M. J., Bencze, W. L., and Gaunt, R., Experientia, 14, 151 (1958).
Wong, T. W., and Warner, N. E., Endocrinology, 74, 284 (1964).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
WHEATLEY, D., CURRIE, A., HAMILTON, A. et al. Adrenal Necrosis induced by 7-Hydroxymethyl-12-methylbenz(a)anthracene and its Prevention. Nature 211, 1311–1312 (1966). https://doi.org/10.1038/2111311a0
Issue Date:
DOI: https://doi.org/10.1038/2111311a0
This article is cited by
-
Effect of stress on the adrenocorticolytic and carcinogenic action of 7,12-dimethylbenz(a)anthracene
Zeitschrift f�r Krebsforschung (1971)
-
Embryopathic Effects of 7,12-Dimethylbenz(a)anthracene and its Hydroxymethyl Derivatives in the Sprague–Dawley Rat
Nature (1970)
-
Effect of metopirone and 3-(1,2,3,4-tetrahydro-1-oxo-2-naphthyl)-pyridine on the metabolism of corticosteroids and DMBA in relation to adrenal necrosis
Experientia (1968)
-
Variations dependent on Age and Diet in the Metabolism of 7,12-Dimethylbenz[a]-anthracene by Rat Liver Homogenates
Nature (1967)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.