Abstract
WHEN platelets from diabetic patients are incubated with acetate carbon-14, a significantly smaller than normal percentage of fatty acid carbon-14 is found in myristic and palmitic acids. Formation of longer-chain fatty acids, particularly saturated and unsaturated 20-carbon fatty acids, is much less affected, resulting in an increased percentage of fatty acid carbon-14 in these fatty acids1–3. Platelets from comatose diabetics show the greatest abnormality1, while those from non-ketotic insulin-dependent diabetics2 and insulin-independent diabetics3 show less marked but similar changes.
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HENNES, A., AWAI, K., HAMMARSTRAND, K. et al. Carbon-14 in Carboxyl Carbon of Fatty Acids formed by Platelets from Normal and Diabetic Subjects. Nature 210, 839–841 (1966). https://doi.org/10.1038/210839a0
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DOI: https://doi.org/10.1038/210839a0
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