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Appearance of Natural Antibodies in Young Rabbits

Nature volume 210, pages 543–544 (1966)Cite this article

Abstract

NATURALLY occurring antibodies to antigens of erythro-cytes, tissues such as liver, and microbes are invariably detectable in the serum of fully grown animals but are not found in the serum of the new-born. Whether these antibodies arise as a result of normal physiological maturation or as a result of inapparent immunization has puzzled immunologists for many years. There is evidence that the blood group and microbial antibodies may be formed as a response to ingested antigens, since their production has been prevented in some cases by rearing the animals in a germ-free environment. Germ-free chicks, for example, promptly developed antibodies to blood group B antigen after the oral administration of Escherichia coli 086, an organism with blood group B antigenic determinants1. The phenomenon of naturally occurring complement-fixing serum substances reactive with extracts of mammalian tissue, including an animal's own tissue, is not readily explained2,3. It is possible that these substances, which are serum globulins, are not antibodies formed in response to antigenic stimulation. When combined with tissue for which they have an affinity, they may conceivably be aggregated and thereby fix complement4.

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References

  1. Springer, G. F., Horton, R. E., and Forbes, M., J. Exp. Med., 110, 221 (1959).

    Article  CAS  Google Scholar 

  2. Kidd, J. G., and Friedewald, W. F., J. Exp. Med., 76, 543 (1942).

    Article  CAS  Google Scholar 

  3. Muschel, L. H., Simonton, L. A., Wells, P. A., and Five, jun., E. H., J. Clin. Invest., 40, 517 (1961).

    Article  CAS  Google Scholar 

  4. Kunkel, H. G., and Tan, E. M., Adv. in Immunol., 4, 351 (1964).

    Article  Google Scholar 

  5. Gordon, H. A., Ann. N.Y. Acad. Sci., 78, 208 (1959).

    Article  ADS  CAS  Google Scholar 

  6. Osawa, E., and Muschel, L. H., J. Immunol, 84, 203 (1960).

    CAS  PubMed  Google Scholar 

  7. Toussaint, A. J., and Muschel, L. H., Nature, 183, 1825 (1959).

    Article  ADS  CAS  Google Scholar 

  8. Atwood, R. P., Fed. Proc., 24, 505 (1965).

    Google Scholar 

  9. Mollison, P. L., Blood Transfusion in Clinical Medicine, third ed., 222 (C. C. Thomas, Springfield, Ill., 1961).

    Google Scholar 

  10. Muschel, L. H., and Treffers, H. P., J. Immunol., 76, 11 (1956).

    CAS  PubMed  Google Scholar 

  11. Muschel, L. H., and Treffers, H. P., J. Immunol., 76, 1 (1956).

    CAS  PubMed  Google Scholar 

  12. Toussaint, A. J., and Muschel, L. H., J. Immunol., 89, 27 (1962).

    CAS  PubMed  Google Scholar 

  13. Howe, P. E., J. Biol. Chem., 53, 479 (1922).

    CAS  Google Scholar 

  14. Fahey, J. L., and Barth, W. F., Proc. Soc. Exp. Biol. and Med., 118, 596 (1965).

    Article  CAS  Google Scholar 

  15. Jerne, N. K., Proc. U.S. Nat. Acad. Sci., 41, 849 (1955).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Serology, Walter Reed Army Institute of Research, Washington, D.C.

    WILLIAM A. HOOK, ANDRE J. TOUSSAINT & LOIS A. SIMONTON

  2. Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota

    Louis H. MUSCHEL

Authors
  1. WILLIAM A. HOOK
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  2. ANDRE J. TOUSSAINT
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  3. LOIS A. SIMONTON
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  4. Louis H. MUSCHEL
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HOOK, W., TOUSSAINT, A., SIMONTON, L. et al. Appearance of Natural Antibodies in Young Rabbits. Nature 210, 543–544 (1966). https://doi.org/10.1038/210543a0

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