Abstract
IN investigating the cell proliferation of normal tissue in rodents individual animals have to be used for each experimental time interval and thus the problem of inter-animal variation is always present. This presents a particular problem when the cell cycle is investigated by the method in which the fraction of mitoses labelled is plotted against time1.
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References
Quastler, H., and Sherman, F. G., Exp. Cell Res., 17, 420 (1959).
Bullough, W. S., Nature, 193, 520 (1962).
Cattaneo, S. M., Quastler, H., and Sherman, F. G., Nature, 190, 923 (1961).
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GRIEM, M. Use of Multiple Biopsies for the Study of the Cell Cycle of the Mouse Hair Follicle. Nature 210, 213–214 (1966). https://doi.org/10.1038/210213a0
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DOI: https://doi.org/10.1038/210213a0
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