Abstract
IT has been demonstrated by Firemark, Barlow and Roth1 that the concentration of pralidoxime (PAM) in the rat brain cortex after a single intravenous injection of PAM-14C is significantly higher than in other brain regions. The present communication reports an attempt to see whether such a relatively small dose of PAM as used by these authors (20 mg/kg) is able to reactivate satisfactorily the phosphorylated cholinesterase in the brain cortex of rats poisoned with lethal doses of paraoxon.
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References
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MILOŠEVIĆ, M., ANDJELKOVIĆ, D. Reactivation of Paraoxon-inactivated Cholinesterase in the Rat Cerebral Cortex by Pralidoxime Chloride. Nature 210, 206 (1966). https://doi.org/10.1038/210206a0
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DOI: https://doi.org/10.1038/210206a0
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