Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Allotypy and Eniotypy

Abstract

INDIVIDUAL, animals of a given species show well-defined, genetically controlled differences in the composition of certain isofunctional proteins. This molecular polymorphism is essentially of two types. The first type is one in which an isofunctional protein such as haemoglobin is present in all individuals of the species and the individuals differ from one another by the amino-acid sequence in limited regions of the molecule. The second type of polymorphism is characterized by the presence or absence of a particular protein in different animals of the same species. We wish to propose here a general nomenclature for these two polymorphic states.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Oudin, J., C.R. Acad. Sci., Paris, 242, 2606 (1956).

    CAS  Google Scholar 

  2. Medawar, P., Nature, 207, 1327 (1965).

    Article  ADS  CAS  Google Scholar 

  3. Cinader, B., Dubiski, S., and Wardlaw, A. C., J. Exp. Med., 120, 897 (1964).

    Article  CAS  Google Scholar 

  4. Cinader, B., and Dubiski, S., Nature, 202, 102 (1964).

    Article  ADS  CAS  Google Scholar 

  5. Cinader, B., Nature, 188, 619 (1960).

    Article  ADS  CAS  Google Scholar 

  6. Cinader, B., and Dubiski, S., in La Tolérance acquise et la Tolérance Naturelle a l'Égard de Substances Antigéniques Définies, Royamount 25–28juin 1962 , edit. by Bussard, A., 255 (Centre National de la Recherche Scientifique, Paris, 1963).

    Google Scholar 

  7. Biggs, R., and Macfarlane, R. G., Human Blood Coagulation and its Disorders, third ed. (Blackwell Scientific Publications, Oxford, 1962).

    Google Scholar 

  8. Stefanini, M., and Dameshek, W., Hemorrhagic Disorders, second ed. (Grune and Stratton, New York, 1962).

    Google Scholar 

  9. Harris, H., Human Biochemical Genetics (Cambridge Univ. Press, London, 1959).

    Google Scholar 

  10. Hsia, D. Y., Inborn Errors of Metabolism (Year Book Publishers, Chicago. 1959).

    Google Scholar 

  11. Aebi, H., Heiniger, J. P., Bütler, R., and Hässig, A., Experientia, 17, 466 (1961).

    Article  CAS  Google Scholar 

  12. Takahara, S., Lancet, ii, 1101 (1952).

  13. Harris, H., in Second Intern. Conf. Congenital Malformations, New York City, July 14–19, 1963 , edit. by International Medical Congress, Ltd., 135 (International Medical Congress, Ltd., New York, 1964).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

CINADER, B., DUBISKI, S. & WARDLAW, A. Allotypy and Eniotypy. Nature 210, 1291–1292 (1966). https://doi.org/10.1038/2101291b0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/2101291b0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing