Abstract
SERUM of pregnant women inactivates oxytocin due to the presence of oxytocinase. Serum of men and non-pregnant women does not inactivate oxytocin. Oxytocinase is thought to be produced by the placenta. This enzyme (E.C. 3.4.1.2) hydrolyses L-cystine-di-β-naphthyl-amide and has been termed ‘cystine aminopeptidase’.
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References
Burstone, M. S., Enzyme Histochemistry and its Application in the Study of Neoplasms (Academic Press, 1962).
Pearse, A. E., Histochemistry, Theoretical and Applied (J. and A. Churchill, London, 1960).
Hanson, H., Second Intern. Cong. Histochemistry and Cytochemistry, 113 (Springer-Verlag, 1964).
Enzyme Nomenclature, Recommendations (1964) of the International Union of Biochemistry, (Elsevier, 1965).
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JAMES, N. Histochemical Demonstration of Oxytocinase in the Human Placenta. Nature 210, 1276–1277 (1966). https://doi.org/10.1038/2101276a0
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DOI: https://doi.org/10.1038/2101276a0
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