Abstract
Malawista and Schubert1 showed that 80 per cent of the chondroitin sulphate present in bovine nasal cartilage could be extracted from the tissue by homogenization in distilled water. Further purification of the extracted material indicated that 15 per cent of the dry weight was protein2 which appeared to be covalently bound to the polysaccharide moiety. Small amounts of keratan sulphate have recently been found in the complex3, and work in this laboratory has indicated that both muco-polysaccharides behave as though they are part of a single complex molecule4.
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References
Malawista, I., and Schubert, M., J. Biol. Chem., 230, 535 (1958).
Gerber, B. R., Franklin, E. C., and Schubert, M., J. Biol. Chem., 235, 2870 (1960).
Gregory, J., and Koden, L., Biochem. Biophys. Res. Commun., 5, 430 (1961).
Goh, A. T. W., and Lowther, D. A. (in preparation).
Kaplan, D., and Meyer, K., Nature, 183, 1267 (1959).
Scott, J. E., in Methods of Biochemical Analysis, edit. by Glick. D., 8, 145 (1960).
Gardell, S., Acta Chem. Scand., 11, 668 (1957).
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GOH, AW., LOWTHER, D. Effect of Age on the Composition of Bovine Nasal Cartilage. Nature 210, 1270–1271 (1966). https://doi.org/10.1038/2101270a0
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DOI: https://doi.org/10.1038/2101270a0
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