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Radioactive (Chromium-51) Heinz Bodies

Abstract

HEINZ bodies are refractile granules appearing within erythrocytes and stainable with certain dyes such as crystal violet1–3. In man, their appearance is often associated with anaemia due to drug administration (for example, phenylhydrazine, menadione) or contact with other agents (for example, aniline dyes), particularly in certain sensitive individuals. Although the granules can be readily prepared experimentally by treatment of animals or isolated erythrocytes with various drugs, their chemical composition is only partially resolved and their metabolic disposition is unknown.

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References

  1. Heinz, R., Virch. Arch. Path. Anat., 122, 112 (1890).

    Article  Google Scholar 

  2. Webster, S. H., Blood, 4, 479 (1949).

    CAS  Google Scholar 

  3. Wintrobe, M. M., Clinical Hematology, 624 (Lea and Febiger, Philadelphia, 1961).

    Google Scholar 

  4. Magos, L., Experientia, 12, 264 (1956).

    Article  CAS  Google Scholar 

  5. Harley, J. D., and Mauer, A. M., Blood, 17, 418 (1961).

    CAS  PubMed  Google Scholar 

  6. Beutler, E., Dern, R. J., and Alving, A. S., J. Lab. Clin. Med., 45, 40 (1955).

    CAS  PubMed  Google Scholar 

  7. Jandl, J., Engle, L. K., and Allen, D. W., J. Clin. Invest., 39, 1818 (1960).

    Article  CAS  Google Scholar 

  8. Gray, S. J., and Sterling, K., J. Clin. Invest., 29, 1604 (1950).

    Article  CAS  Google Scholar 

  9. Ultmann, J. E., Fish, W., and Hyman, G. A., Cancer Res., 16, 885 (1956).

    CAS  PubMed  Google Scholar 

  10. Anderson, H., and Turner, J. C., J. Clin. Invest., 39, 1 (1960).

    Article  CAS  Google Scholar 

  11. Dodge, J. T., Mitchell, C., and Hanahan, D. J., Arch. Biochem. Biophys., 100, 119 (1963).

    Article  CAS  Google Scholar 

  12. Rifkind, R. A., and Danon, D., Blood, 25, 885 (1965).

    CAS  PubMed  Google Scholar 

  13. Harley, J. D., Mauer, A. M., Blood, 16, 1722 (1960).

    CAS  PubMed  Google Scholar 

  14. Beaven, G. H., and White, J. C., Nature, 173, 389 (1954).

    Article  ADS  CAS  Google Scholar 

  15. Cohen, G., and Hochstein, P., J. Pharm. Exp. Therap., 147, 139 (1965).

    CAS  Google Scholar 

  16. Cohen, G., and Hochstein, P., Biochem., 3, 895 (1964).

    Article  CAS  Google Scholar 

  17. Cohen, G., and Hochstein, P., Science, 134, 1756 (1961).

    Article  ADS  CAS  Google Scholar 

  18. Bracci, R., Seeler, R., Rudolph, N., Kochen, J. A., and Gross, R. T., Trans. Sec. Ped. Res., 23, (1965) (Abstract).

  19. Dacie, J. V., Grimes, A. J., Meisler, A., Steingold, L., Hemsted, E. H., Beaven, G. H., and White, J. C., Brit. J. Hematol., 10, 388 (1964).

    Article  CAS  Google Scholar 

  20. Beritic, T., Blood, 25, 999 (1965).

    CAS  PubMed  Google Scholar 

  21. Malcolm, D., Ranney, H. M., and Jacobs, A. S., Blood, 21, 8 (1963).

    CAS  Google Scholar 

Download references

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MARTINEZ, M., LO, A., COHEN, G. et al. Radioactive (Chromium-51) Heinz Bodies. Nature 210, 1064–1066 (1966). https://doi.org/10.1038/2101064a0

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