Abstract
IT was recently reported1 that the sulphydryl (—SH) agent, parachloromercuribenzoate (PCMB), causes superprecipitation of actomyosin gel. Masking of an —SH group appears to prevent interaction between ATP and some inhibitory site on the protein, thus enabling ATP to induce superprecipitation through reaction with another site. If this phenomenon is related to changes occurring in the actomyosin system during muscle activity, then —SH agents should be expected to produce contraction. Accordingly, several such agents were tested on skeletal muscle, and they were found to cause various types of contractile phenomena.
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OKAMOTO, M., KUPERMAN, A. Muscle Contraction produced by Sulphydryl Inhibitors. Nature 210, 1062–1063 (1966). https://doi.org/10.1038/2101062a0
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DOI: https://doi.org/10.1038/2101062a0
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