Abstract
IN 1956, Můr, Zaruba and Charamza1 reported myelin degeneration in twenty-one rabbits, of which sixteen had received repeated intravenous injections of α-benzoin oxime, and five had received repeated intravenous injections of diethyldithiocarbamate. The lesion, which was most marked in the spinal cord, was compared to tat seen in swayback in lambs and disseminated sclerosis in man. They also reported a decrease in blood copper levels in nine out of twelve rabbits after intravenous administration of α-benzoin oxime, and in two out of two rabbits following intravenous injection of diethyldithiocarbamate.
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References
Můr, J., Zaruba, M., and Charamza, O., Acta Universitatis PalacKianae Olomucensis, 11, 141 (1956).
Howell, J. McC., Nature, 201, 83 (1964).
Sunderman, jun., E. W., White, J. C., and Sunderman, F. W., Amer. J. Med. Sci., 34, 875 (1963).
Thorn, G. D., and Ludwig, R. A., in The Dithiocarbamates and Related Compounds, (Elsevier Publishing Co., 1962).
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EDINGTON, N., HOWELL, J. Changes in the Nervous System of Rabbits following the Administration of Sodium Diethyldithiocarbamate. Nature 210, 1060–1062 (1966). https://doi.org/10.1038/2101060b0
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DOI: https://doi.org/10.1038/2101060b0
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