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Action of Riley's Enzyme-elevating Virus on Tumour-bearing Mice

Nature volume 209, pages 929–930 (1966)Cite this article

Abstract

RILEY virus (RV) is a passenger agent occurring in most mouse tumours which are subjected to repeated transplanting passages1–6. The influence of this virus on tumour-bearing hosts has not yet been clarified, though its stimulating and accelerating effects on tumour-growth have been discussed3,5. There is a significant elevation of LDH-values after virus-infection of tumour-bearing mice as compared with tumour-free hosts1,3,5 (termed ‘tumour-virus synergism’ by Riley5). This phenomenon is of special interest, because the natural occurrence of RV is almost restricted to tumour-bearing mice. Enhanced values of plasma-LDH in tumour hosts7 might be induced mainly by RV. We have investigated the effects of RV on three different tumours of mice previously free of the agent.

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Authors and Affiliations

  1. Institute of Pathology, University of Munich, Munich

    A. GEORGII, L. THORN & H. WRBA

Authors
  1. A. GEORGII
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  2. L. THORN
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  3. H. WRBA
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GEORGII, A., THORN, L. & WRBA, H. Action of Riley's Enzyme-elevating Virus on Tumour-bearing Mice. Nature 209, 929–930 (1966). https://doi.org/10.1038/209929a0

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