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A Naturally Occurring Foetal Haemoglobin Hybrid

Nature volume 209, pages 721–722 (1966)Cite this article

Abstract

RECENT evidence1 has shown that abnormal haemoglobins can result from the mutation of genes controlling the synthesis of α-, β- and δ-chains in the adult as well as γ-chains in the foetus. According to this concept, it should be possible for an individual to inherit simultaneously a gene for an α- as well as a β-chain abnormality. Such a person could possess eight haemoglobins: two completely normal (Hb-A and A2), the abnormal α-chain with a normal β-chain (α2xB2), the normal α-chain with the abnormal β-chain (α2Bx2), both abnormal chains (α2xBx2), the abnormal α- with the normal δ-chain (α2xδ2), and finally the abnormal α- with a normal γ-chain (α2xγ2). One of us2 has already discussed the occurrence of minor haemoglobins of cord blood and the relationship of Hb-H and Bart's to each other and to Hb-F.

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References

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Author information

Authors and Affiliations

  1. Hemoglobin Research Laboratory, Department of Clinical Laboratory Sciences, University of Mississippi Medical Center, Jackson, Mississippi

    ROBERT B. THOMPSON, RICHARD L. WARRINGTON, J. ODOM & WARREN N. BELL

Authors
  1. ROBERT B. THOMPSON
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  2. RICHARD L. WARRINGTON
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  3. J. ODOM
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  4. WARREN N. BELL
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THOMPSON, R., WARRINGTON, R., ODOM, J. et al. A Naturally Occurring Foetal Haemoglobin Hybrid. Nature 209, 721–722 (1966). https://doi.org/10.1038/209721a0

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