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N-Hydroxy-2-fluorenylbenzamide, an Aryl-hydroxamic Acid with High Carcinogenic Activity

Nature volume 209, pages 202–203 (1966)Cite this article

Abstract

FOR investigations of the mechanism of action of carcinogenic arylhydroxamic acids we have prepared the new hydroxamic acid, N-hydroxy-2-fluorenylbenzamide (N-OH-2-BAF) (Ia), an analogue of the carcinogen, N-hydroxy-2-fluorenylacetamide (N-OH-2-AAF) (Ib). We have tested this compound for its carcinogenicity and found it to be an extremely active agent. We wish to report here the results of tests in which the carcinogenic activities of N-OH-2-BAF, of its parent amide, N-2-fluorenylbenzamide (BAF) (II), and of N-OH-2-AAF (ref. 1) for the young female Holtzman rat have been compared.

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Authors and Affiliations

  1. Cancer Research Laboratory, Veterans Administration Hospital, Minneapolis

    H. R. GUTMANN, S. B. GALITSKI & W. A. FOLEY

  2. the Department of Biochemistry, University of Minnesota, Minneapolis

    H. R. GUTMANN, S. B. GALITSKI & W. A. FOLEY

Authors
  1. H. R. GUTMANN
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  2. S. B. GALITSKI
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  3. W. A. FOLEY
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GUTMANN, H., GALITSKI, S. & FOLEY, W. N-Hydroxy-2-fluorenylbenzamide, an Aryl-hydroxamic Acid with High Carcinogenic Activity. Nature 209, 202–203 (1966). https://doi.org/10.1038/209202b0

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