Abstract
AN earlier investigation1 revealed that during citrate dissimilation by non-proliferating suspensions of Klebsiella aerogenes, diphtheria toxin caused increased accumulation of pyruvic and α-ketoglutaric acid. This observation suggested that diphtheria toxin acts by diminishing the utilization of keto-acids in tissues. It was, therefore, decided to investigate the effect of diphtheria toxin on the keto-acid content of blood and tissues in guinea-pigs.
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References
Agarwal, S. C., J. Path. Bact., 87 (1), 186 (1964).
Friedemann, T. E., and Haugen Gladys, E., J. Biol. Chem., 147, 415 (1948).
Agarwal, S. C., J. Path. Bact., 79 (2), 313 (1960).
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AGARWAL, S. Accumulation of Keto-acids in Tissues during Diphtheria Intoxication. Nature 208, 914–915 (1965). https://doi.org/10.1038/208914a0
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DOI: https://doi.org/10.1038/208914a0
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