Abstract
ALLOGENEIC bone marrow transplantations in 1,000-r. X-irradiated dogs are therapeutically ineffective. Our earlier results1 made it possible for us to suggest that transplanted haemopoietic cells became immunologically active against the recipient's lymphocyte antigens. All the dogs invariably indicated within 6–7 days of transplantation profound leucopenia followed by a sharp increase in white blood cell count at the cost of peculiar mononuclear hyperbasophilic cells resembling immune cell precursors or transformed lymphocytes in phytohaemagglutinin leucocyte cultures. On the next day only lymphocytes were observed in the blood; their count progressively decreased, and the animals died.
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Transplantation of Tissues and Cells, edit. by Billingham, R. E. (Silvers, W. K., Philadelphia, 1961).
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CHERTKOV, I., MAXIMENKO, A., NOVIKOVA, M. et al. Bone Marrow Allografts in Thymectomized X-irradiated Dogs. Nature 208, 399–400 (1965). https://doi.org/10.1038/208399a0
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DOI: https://doi.org/10.1038/208399a0
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