Abstract
INTESTINAL tumours, though very rare in laboratory rodents, have been induced by several types of carcinogenic agents, including polycyclic aromatic hydrocarbons, 4-dimethylaminostilbene, 2-acetyl-aminofluorene and radiation1,2. However, so far, no such tumours have been induced by alkylnitroso-compounds, which are able to induce tumours in many organs3. Attempts to induce tumours of the colon by repeated rectal application of diethylnitrosamine led to liver, but not to local, tumours4.
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References
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SCHOENTAL, R. Induction of Intestinal Tumours by N-Ethyl-N-nitrosourethane. Nature 208, 300 (1965). https://doi.org/10.1038/208300a0
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DOI: https://doi.org/10.1038/208300a0
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