Abstract
THE technique of ‘fingerprinting’ developed by Ingram1 has proved to be of great value in the molecular analysis of haemoglobins. In principle, it is a combined paper electrophoresis and chromatography of the peptides released by enzymatic digestion, of haemoglobin. This enables the location of a probably occurring difference to a particular peptide. The method has proved its importance especially in the detection of amino-acid differences in normal and abnormal haemoglobins. This communication describes a modified system for fingerprinting haemoglobins.
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References
Ingram, V. M., Biochim. Biophys. Acta, 28, 539 (1958).
Michl, H., Monatsch. Chem., 82, 489 (1951).
Baglioni, C., Biochim. Biophys. Acta, 48, 392 (1961).
Hill, R. L., Swenson, R. T., and Schwartz, H. C., Blood, 19, 573 (1962).
Tolnnies, G., and Kolb, J. J., Anal. Chem., 23, 189 (1951).
Smith, I., Nature, 171, 43 (1953).
Baldridge, R. C., and Lewis, H. B., J. Biol. Chem., 202, 169 (1953).
Acher, R., and Crocker, C., Biochim. Biophys. Acta, 9, 704 (1952).
Efremov, G., Brænd, M., and Osterhoff, D. R. (in preparation).
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EFREMOV, G. A Modification System for Fingerprinting Haemoglobin. Nature 208, 298–299 (1965). https://doi.org/10.1038/208298a0
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DOI: https://doi.org/10.1038/208298a0
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