Abstract
THE isolated superfused carotid body preparation described by Eyzaguirre and Lewin1, and used by them to investigate some properties of the carotid body, is a useful method for investigating chemoreceptor activity without need for concern about changes in the blood supply. This communication reports the results of an examination of the effects of a number of compounds on the activity of chemoreceptors in such a preparation. Some of these drugs would normally be expected to modify the blood flow through the carotid body and hence indirectly to affect the chemoreceptor activity. The changes in activity which they induce thus, here, represent the direct actions of drugs on the chemoreceptors. In addition, the effect of changes in the calcium ion concentration of the superfusate has been investigated because there is evidence2–4 that transmitter release at a number of sites may be related to calcium ion concentration.
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References
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BISCOE, T. Some Effects of Drugs on the Isolated Superfused Carotid Body. Nature 208, 294–295 (1965). https://doi.org/10.1038/208294a0
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DOI: https://doi.org/10.1038/208294a0
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