Abstract
PREVIOUS workers have shown that sera of various mammals are capable of binding plutonium. Hunts and Barron1 prepared serum from dogs which had been intravenously injected with a hexavalent plutonium citrate complex. Electrophoresis of the serum in a Tiselius type of apparatus showed that the β-globulin fraction combines with the plutonium. Beliayev2, using papor electrophoretic methods, showed that plutonium is bound principally to the globulin fractions. The serum used in this latter piece of work was obtained from rats 24 h after intraperitoneal injection of a tetravalent plutonium citrate complex. The results obtained by Beliayev were not very reproducible, due possibly to buffer salt interactions and the influence of the electric field. Accordingly we have measured the distribution of intravenously injected tetravalent plutonium in the blood serum of the rat. The results presented here show that in blood obtained from the rat within 0.5 h of injection, the plutonium is bound to the transferrin proteins.
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References
Hunts, J. A., and Barron, E. S. G., U.S. Atomic Energy Comm. Rep. M.D.D.C. 1268, Argonne National Laboratory (1947).
Beliayev, Yu. A., Meditsinkaya Radiologiya, 4, 45 (1959); in English, U.S. Atomic Energy Comm. Rep. AEC-tr-3878, Argonne National Laboratory (1959).
Gelotte, B., Flodin, P., and Killander, J., Arch. Biochem. Biophys., Supp. 1, 319 (1962).
Amiel, S., Anal. Chem., 34, 1683 (1962).
Smith, I., in Chromatographic and Electrophoretic Techniques, 56 (William Heinemann Medical Books, Ltd., London, 1960).
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BOOCOCK, G., POPPLEWELL, D. Distribution of Plutonium in Serum Proteins following Intravenous Injection into Rats. Nature 208, 282–283 (1965). https://doi.org/10.1038/208282a0
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DOI: https://doi.org/10.1038/208282a0
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