Abstract
WITHIN the group of non-spherocytic haemolytic anaemias classified as ‘type 11’ by Selwyn and Dacie1, Valentine, Tanaka and Miwa2 found a specific erythrocyte deficiency of pyruvate kinase (PK). The leucocyte PK activity in patients with this disease is normal2, suggesting that the genetic control of leucocyte PK differs from that of red cell PK. Electrophoretic differences among PK preparations from rat kidney, liver, cardiac muscle, brain and skeletal muscle were reported by Fellenberg et al.3. Chromatographic, electrophoretic, solubility and structural differences between the normal human leucocyte and red cell PK have been presented4.
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References
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CAMPOS, J., KOLER, R. & BIGLEY, R. Kinetic Differences between Human Red Cell and Leucocyte Pyruvate Kinase. Nature 208, 194–195 (1965). https://doi.org/10.1038/208194a0
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DOI: https://doi.org/10.1038/208194a0
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