Abstract
VARIATIONS in the physico-chemical characteristics of glucose-6-phosphate dehydrogenase (G-6-PD) have been described both in individuals with normal1–4 and deficient5–11 enzyme activity. Recently, Kirkman, McCurdy and Naiman12 have reported on the characteristics in three unrelated Chinese males with G-6-PD deficiency. They found that the G-6-PD migrated slightly faster than normal G-6-PD but the migration was not quite as fast as that of (A–) G-6-PD observed in Negroes. The enzyme had slightly more thermolability, a bimodal pH optimum curve similar to that of the Mediterranean variant, abnormally low Kms for G-6-P and TPN and relatively greater utilization of G-6-P analogues.
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WONG, P., SHIH, LY., HSIA, DY. et al. Characterization of Glucose-6-phosphate Dehydrogenase among Chinese. Nature 208, 1323–1324 (1965). https://doi.org/10.1038/2081323a0
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DOI: https://doi.org/10.1038/2081323a0
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