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Synthesis of the α1-Glycoprotein (Darcy) of Rat Serum by the Liver

Nature volume 208, pages 1221–1222 (1965)Cite this article

Abstract

AN α1-glycoprotein present in normal rat serum has been observed to increase markedly in concentration in conditions characterized by tissue injury or cell death1. Based on the reduced response of the protein to tissue injury in partially hepatectomized rats, it has been suggested that the liver is the tissue of origin2,3. The present communication reports the demonstration of the synthesis of α1-glycoprotein (Darcy) by the liver during the acute phase of an inflammatory response.

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References

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Authors and Affiliations

  1. Department of Medical Microbiology and Immunology, Center for the Health Sciences, University of California, Los Angeles

    H. E. WEIMER & D. C. BENJAMIN

  2. Chester Beatty Research Institute, Royal Cancer Hospital, London

    D. A. DARCY

Authors
  1. H. E. WEIMER
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  2. D. C. BENJAMIN
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  3. D. A. DARCY
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WEIMER, H., BENJAMIN, D. & DARCY, D. Synthesis of the α1-Glycoprotein (Darcy) of Rat Serum by the Liver. Nature 208, 1221–1222 (1965). https://doi.org/10.1038/2081221a0

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