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A Screening Test for Substances inhibiting the Cancer Coagulative Factor

Nature volume 208, pages 1008–1009 (1965)Cite this article

Abstract

MALIGNANT tissues produce a thermolabile coagulative factor which diffuses out of cells and lays down fibrin1–3. Tumours have little fibrinolytic activity and the unresolved fibrin around them leads to the growth of connective tissue, blood vessels, and lymph vessels, which form the stroma of the tumour and help the invasion of healthy tissues2. Four fractions of the cancer coagulative factor have been identified4. Three of these are also present in placental chorion, but only very little of one fraction is found in a few normal tissues4. It has been known for some time that watery extracts of placenta have a thromboplastic activity5–7 and that placental extracts cause multiple blood clots when they are injected into animals6,7. It seemed probable that the coagulative effects of cancer and chorion are due to similar factors.

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Authors and Affiliations

  1. Evans Medical Research Laboratories, Speke, Liverpool, 24

    E. M. GLASER & P. SPINK

  2. Trinity College, Dublin

    R. A. Q. O'MEARA

Authors
  1. E. M. GLASER
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  2. P. SPINK
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  3. R. A. Q. O'MEARA
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GLASER, E., SPINK, P. & O'MEARA, R. A Screening Test for Substances inhibiting the Cancer Coagulative Factor. Nature 208, 1008–1009 (1965). https://doi.org/10.1038/2081008a0

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