Abstract
GLUCOSE cycloacetoacetate (GCA) while hydrolysed with dilute hydrochloric acid has been found to have beneficial effects in experimental diabetes1–3. It has also recently been observed in this laboratory to facilitate transmethylation reactions in E. coli4. It was reported earlier by Saikia, Brahmankar and Nath5 that hydrolysed glucose cycloacetoacetate in a daily dose of 80 mg/100 g body-wt can cause considerable desaturation of the liver fat, which, according to Schoenheimer and Rittonberg6, is an indication of increased fat metabolism. Nath and Saikia7,8 have also observed earlier the prevention of atherosclerotic and hyperlipaemic conditions in animals by the hydrolysed product of glucose cycloacetoacetate (GCAH). Investigations were therefore undertaken to observe the lipotropic effect of GCAH in experimental animals. Because vitamin B12 is known to have a lipotropic effect it was also thought desirable to study the effect of very small doses of vitamin B12 in partially hepatectomized animals.
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NATH, N., YAWALKAR, V. & NATH, M. Effect of Hydrolysed Glucose Cycloacetoacetate in the Prevention of Fatty Infiltration in the Liver. Nature 208, 1001 (1965). https://doi.org/10.1038/2081001a0
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DOI: https://doi.org/10.1038/2081001a0
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