Abstract
SOME time ago we discussed the formation of radicals in irradiated samples of methionine1 and bovine serum albumin2. In the case of methionine, in which the bivalent sulphur is present in the form of a thioether, X-irradiation forms radicals of the alkyl-type, but ultra-violet irradiation (254 mµ) localizes them at the sulphur atom. Moreover, ultra-violet light is able to quench the alkyl-type radicals. In the case of bovine serum albumin, X-irradiation as well as ultra-violet light forms a complex electron spin resonance spectrum consisting of a glycylglycine- and a sulphur-radical3. The portion of the sulphur radical part becomes bigger after ultra-violet irradiation. By ultra-violet irradiation of longer wave-length (λ > 300 mµ) the X-ray conditioned radical state at the carbon atom is transferred to the SS- or SH-groups of the albumin molecule. In the following investigations we controlled the behaviour of the bivalent sulphur in the form of a thiolactone ring compound, that is, a thioester, homocysteinethiolactone (HCT):
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Mönig, H., and Koch, R., Nature, 202, 289 (1964).
Koch, R., and Mönig, H., Nature, 203, 859 (1964).
Gordy, W., and Shields, H., Rad. Res., 9, 611 (1958).
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KOCH, R., MÖNIG, H. Electron Spin Resonance Investigations of Ultra-violet and X-irradiated Homocysteine-thiolactone. Nature 208, 86 (1965). https://doi.org/10.1038/208086a0
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DOI: https://doi.org/10.1038/208086a0
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