Abstract
DECREASES in the catecholamine content of the myocardium have been found to occur in animals subjected to prolonged periods of hypoxia1 and of myocardialischaemia2. Results recently obtained in this laboratory3,4, however, suggest that release and subsequent loss of cardiac cate-cholamines from their storage site may be a more immediate response of the animal to arrest of the coronary circulation and to myocardial anoxia in general. In the work recorded here the isolated perfused heart was selected as a suitable object for approaching this problem experimentally and, at the same time, independently of the influence of nervous activity. Using the isolated perfused adrenal gland Bülbring et al.5 and Cession-Fossion6 had been able to demonstrate a direct mobilizing action of anoxia on the adrenaline stores of this organ.
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References
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WOLLENBERGER, A., SHAHAB, L. Anoxia-induced Release of Noradrenaline from the Isolated Perfused Heart. Nature 207, 88–89 (1965). https://doi.org/10.1038/207088a0
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DOI: https://doi.org/10.1038/207088a0
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