Abstract
IT has been demonstrated that patients with liver disorders are particularly susceptible to ammonia intoxication1. Since ammonia is detoxified by urea synthesis, study of the enzymes of the Krebs–Hensleit cycle in the normal and abnormal liver might provide useful information. Decrease of liver arginase activity in patients suffering from cirrhosis and hepatic coma has been reported by Ugarte, Pino and Valenzuela2. In our study, arginase was crystallized from a ‘normal’ human and a cirrhotic human liver and the catalytic efficiency of the enzymes from the two sources was compared.
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References
Manning, R. T., Biochemical Clinics, 3, 225 (1964).
Ugarte, G., Pino, M. E., and Valenzuela, J., J. Lab. Clin. Med., 57, 359 (1961).
Bach, S. J., and Killip, J. D., Biochim. Biophys. Acta, 19, 273 (1958).
Van Slyke, D. D., and Archibald, R. M., J. Biol. Chem., 165, 293 (1946).
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SUMMER, D., MANNING, R. Crystallization of Arginase from Normal and Cirrhotic Human Liver. Nature 207, 79–80 (1965). https://doi.org/10.1038/207079a0
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DOI: https://doi.org/10.1038/207079a0
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