Abstract
THE study of transplantation antigens in humans depends to a large extent on the existence of suitable immunological techniques in vitro. In animal experiments a cytotoxic technique was found to have wide application for the study of transplantation antigens. It has been clearly shown that iso-antisera directed against histocompatibility antigens can lyse various nucleated target cells in vitro in the presence of complement, usually derived from guinea-pig serum1.
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References
Gorer, P. A., and O'Gorman, P., Transpl. Bull., 3, 142 (1956).
Möller, E., and Möller, G., J. Exp. Med., 115, 527 (1962).
Coons, A. H., and Kaplan, M. H., J. Exp. Med., 91, 1 (1950).
Möller, G., J. Exp. Med., 114, 415 (1961).
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MÖLLER, E., EKLUND, A. Cytotoxic Effect of Iso-antibodies directed against ABO and Rh Antigens on Human Lymph Node Cells. Nature 206, 731–732 (1965). https://doi.org/10.1038/206731a0
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DOI: https://doi.org/10.1038/206731a0
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