Abstract
GILLMAN et al. first observed the teratogenic activity of trypan blue in 1948 (ref. 1), and the dye has since become widely used as a teratogenic agent for laboratory work. The recent development of a system for the cultivation of post-implantation rat embryos in vitro2 has made it possible to investigate the direct action of trypan blue on the isolated embryo.
Similar content being viewed by others
Article PDF
References
Gillman, J., Gilbert, C., Gillman, T., and Spence, I., S. Afr. J. Med. Sci., 13, 2, 47 (1948).
New, D. A. T., and Stein, K. F., J. Embryol. Exp. Morph., 12, 101 (1964).
Waddington, C. H., and Carter, T. C., J. Embryol. Exp. Morph., 1, 167 (1953).
Wilson, J. G., Beaudoin, A. R., and Free, H. J., Anat. Rec., 133, 175 (1959).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
TURBOW, M. Teratogenic Effect of Trypan Blue on Rat Embryos cultivated in vitro. Nature 206, 637 (1965). https://doi.org/10.1038/206637a0
Issue Date:
DOI: https://doi.org/10.1038/206637a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.