Abstract
ALTHOUGH several highly potent antimetabolites of serotonin, for example, hydrazindole, BAS and others, have been known for several years1,2, they have been used very little, either in pharmacological research or in clinical medicine. This has been primarily because the compounds are difficult to synthesize. About the only antiserotonins now in use are lysergic acid diethylamide (LSD) and the related 1-methyl butanolamide (UML). These latter, although they have severe disadvantages (they affect the mind) when compared with the synthetic antiserotonins mentioned here, are often used in preference to them because they are commercially available. Even LSD and UML, however, are expensive.
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DOMBRO, R., VAN DER HOEVEN, T. & WOOLLEY, D. An Easily Obtainable Antiserotonin which has Little Effect on the Brain. Nature 206, 631–632 (1965). https://doi.org/10.1038/206631a0
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DOI: https://doi.org/10.1038/206631a0
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