Abstract
WHEN a second dose of a drug is administered immediately after the apparent disappearance of the pharmacological effect of the initial dose, a considerably greater and more prolonged effect may be obtained1. The purpose of this communication is to suggest a pharmacokinetic basis for this apparent potentiation.
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References
Bush, G. H., and Baraka, A., Brit. J. Anaesth., 36, 356 (1964).
Bellville, T. W., Cohen, E. N., and Hamilton, J., Clin. Pharmacol. and Therap., 5, 35 (1964).
Levy, G., Brit. J. Anaesth., 36, 694 (1964).
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LEVY, G. Apparent Potentiating Effect of a Second Dose of Drug. Nature 206, 517–518 (1965). https://doi.org/10.1038/206517a0
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DOI: https://doi.org/10.1038/206517a0
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