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Anti-convulsive Action of Gamma-Aminobutyryl Choline

Nature volume 206, pages 514–515 (1965)Cite this article

Abstract

γ-AMINOBUTYRYL choline (GABA-choline) is a substance isolated by Kuriaki et al.1 from the trichloroacetate-soluble fraction of normal dog brain, and it was shown by Takahashi et al.2 that this substance had a pronounced suppressive action against the local electrical response to direct electrical stimulation of the cerebral cortex. In the work recorded here, the anticonvulsive action of this substance was examined in detail in the rabbit, dog and ep-mouse3,4. Convulsions can be regularly induced in animals by intravenous injection of a given concentration of ‘Metrazol’ at a set speed, and a generalized clonic seizure followed by a tonic seizure always occurs when a certain quantity has been injected. The effect of GABA-choline on this seizure was examined.

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References

  1. Kuriaki, K., Yakushiji, T., Noro, T., Shimizu, T., and Saji, S., Nature, 181, 1336 (1958).

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  2. Takahashi, H., Nagashima, A., and Koshino, C., Nature, 182, 1443 (1958).

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  3. Imaizumi, K., Ito, S., Kutukake, G., Takezawa, T., Fujiwara, K., and Tukikawa, K., Bull. Exp. Animals, 8, 6 (1959).

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  4. ep-mouse: the name of a strain of mouse in which seizures are usually induced by postural stimulation (abbr.epileptic mouse).

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Authors and Affiliations

  1. Department of Neurosurgery, Osaka University Medical School, Osaka, Japan

    HAJIME ASHIDA, NAOJI TAKEUCHI, AKITANE MORI & DENNOSUKE JINNAI

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  1. HAJIME ASHIDA
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  2. NAOJI TAKEUCHI
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  3. AKITANE MORI
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  4. DENNOSUKE JINNAI
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ASHIDA, H., TAKEUCHI, N., MORI, A. et al. Anti-convulsive Action of Gamma-Aminobutyryl Choline. Nature 206, 514–515 (1965). https://doi.org/10.1038/206514a0

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  • DOI: https://doi.org/10.1038/206514a0

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