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Structure-Phytoactivity Relationships in the Penicillins

Abstract

PREVIOUS tests on various fermentation products using our duckweed (Lemna minor) test1 have shown penicillin G, 6-(phenylacetamido) penicillanic acid, to be an outstanding plant growth-stimulating substance1,2. The recent availability of the penicillin nucleus, 6-amino-penicillanic acid (6-APA), which is as active in stimulating duckweed growth as penicillin G, has afforded access to a variety of ‘semi-synthetic’ penicillins and the opportunity to study their relationship to penicillin G in the duckweed test.

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NICKELL, L., CELMER, W. Structure-Phytoactivity Relationships in the Penicillins. Nature 206, 302–304 (1965). https://doi.org/10.1038/206302a0

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