Abstract
As was recently reported by de Matteis and Rimington1, administration of large doses of griseofulvin in mice causes marked disturbances of porphyrin metabolism resulting in a picture of combined erythropoietic and hepatic porphy-ria. The proto-porphyrin-level increases in faeces and circulating red blood cells, and bone marrow becomes fluorescent. On the other hand, urinary copro-porphyrin, δ-aminolaevulinic acid (ALA) and porphobilinogen (PBG) rise significantly and proto-porphyrin accumulates in the liver.
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References
de Matteis, F., and Rimington, C., Brit. J. Dermatol., 75, 91 (1963).
Gajdos, A., and Gajdos-Török, M., Lancet, ii, 175 (1961).
Gajdos, A., and Gajdos-Török, M., C. R. Soc. Biol. Paris, 161, 1565 (1962).
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Gajdos, A., and Gajdos-Török, M., Nature, 199, 1093 (1963).
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GAJDOS, A., GAJDOS-TÖRÖK, M. Effect of Adenosine-5-monophosphoric Acid or Inosine on Porphyria caused by Griseofulvin in Rats. Nature 206, 297–298 (1965). https://doi.org/10.1038/206297a0
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DOI: https://doi.org/10.1038/206297a0
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