Abstract
X-IRRADIATION has been shown to interfere with some biosynthetic processes in the cell nucleus of the regenerating liver. A disturbance of DNA synthesis1–3 and of nuclear RNA turnover4 was noted when animals were irradiated with moderate doses of X-rays in the early phase of liver regeneration (2–6 h after partial hepatectomy in the case of RNA), but no effect was observed after X-irradiation in the later stages within 24 h after operation. Similarly, an inhibitory effect of X-irradiation on the total protein turnover in the 23-h regenerating liver was reported to occur in animals exposed to lethal doses of X-irradiation 2–6 h after partial hepatectomy, but not in those irradiated 18 h after operation5. The present communication reports the effect of whole-body X-irradiation, at different time intervals within 24 h after partial hepatectomy, on ammo-acid incorporation into proteins of cell nuclei isolated from a 24-h regenerating liver.
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ŠESTAN, N. Effect of Whole-body X-irradiation on 14C-Leucine Incorporation into Proteins of Cell Nuclei of Regenerating Rat Liver. Nature 205, 615 (1965). https://doi.org/10.1038/205615a0
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DOI: https://doi.org/10.1038/205615a0
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