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Metabolic Effect of Epinephrine on the QO2 of the Arrested Isolated Perfused Rat Heart

Nature volume 205, pages 602–603 (1965)Cite this article

Abstract

SYMPATHETIC amines increase the oxygen consumption of the myocardium and it has usually been assumed that this is related primarily, if not exclusively, to the increase effected in rate and contractility. The present investigation demonstrates an increase in myocardial oxygen consumption due to epinephrine during potassium-induced cardiac arrest, that is, in the absence of any chronotropic or inotropic effect. This metabolic increase in oxygen consumption is accompanied by an increase in glycerol release into the perfusion medium, suggesting that the rate of utilization of endogenous lipids rises.

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References

  1. Morgan, H. E., Henderson, M. J., Regan, D. M., and Parks, C. R., J. Biol. Chem., 236, 253 (1961).

    CAS  PubMed  Google Scholar 

  2. Opie, L. H., Shipp, J. C., Evans, J. B., and LeBoeuf, B., Amer. J. Physiol., 203, 839 (1962).

    CAS  PubMed  Google Scholar 

  3. Dole, V. P., J. Clin. Invest., 35, 150 (1956).

    Article  CAS  Google Scholar 

  4. Vaughan, M., J. Biol. Chem., 237, 3354 (1962).

    CAS  PubMed  Google Scholar 

  5. Weisfeldt, M. L., and Gilmore, J. P., Fed. Proc., 28, 357 (1964).

    Google Scholar 

  6. Berne, R. M., Circ. Res., 6, 644 (1958).

    Article  CAS  Google Scholar 

  7. Hollenberg, C. H., Raben, M. S., and Astwood, E. B., Endocrinol., 68, 589 (1961).

    Article  CAS  Google Scholar 

  8. Garland, P. B., and Randle, P. J., Nature, 199, 381 (1963).

    Article  ADS  CAS  Google Scholar 

  9. Alousi, A. A., and Mallov, S., Amer. J. Physiol., 206, 603 (1964).

    CAS  PubMed  Google Scholar 

  10. Challoner, D. R., and Steinberg, D., Clin. Res., 12, 177 (1964).

    Google Scholar 

  11. Klocke, F. J., Kaiser, G. A., Ross, J., and Braunwald, E., Physiologist, 7, 180 (1964).

    Google Scholar 

Download references

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Authors and Affiliations

  1. Laboratory of Metabolism, National Heart Institute, National Institutes of Health, Bethesda, Maryland

    DAVID R. CHALLONER & DANIEL STEINBERG

Authors
  1. DAVID R. CHALLONER
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  2. DANIEL STEINBERG
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CHALLONER, D., STEINBERG, D. Metabolic Effect of Epinephrine on the QO2 of the Arrested Isolated Perfused Rat Heart. Nature 205, 602–603 (1965). https://doi.org/10.1038/205602b0

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  • DOI: https://doi.org/10.1038/205602b0

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