Abstract
ONE of the ‘spots’ frequently appearing on paper chromatograms of the phenolic acids in human urine has been examined in these laboratories for some six years, since it was recognized as being of complex nature. Normally it appears to consist of a mixture of 4-hydroxy-3-methoxy- and 3-hydroxy-4 methoxyphenylhydracrylic acids, both probably largely derived from dietary chlorogenic acid, the latter isomer sometimes being observed in relatively large amounts following the consumption of citrus fruits containing the flavonoid hesperidin1. However, at least two other strongly acidic substances having rather similar RF values have occasionally been detected, particularly in extracts prepared from urines which have been refluxed with acid in order to destroy the hydracrylic acids. The chromatographic properties of these compounds are recorded in Table 1.
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SMITH, P. Pathological Excretion of 4-Hydroxy-3-methoxyphenyllactic Acid. Nature 205, 1236 (1965). https://doi.org/10.1038/2051236a0
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DOI: https://doi.org/10.1038/2051236a0
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