Abstract
THESE experiments were started to test the flux predictions made by Noble1 from his equations used to describe the action potential of Purkinje fibres. The experiments were done on frog ventricle, as this is the most suitable tissue histologically. Although the results are in general agreement with these equations, they suggest a considerably greater diminution in the potassium permeability during the plateau of the cardiac action potential than that used for the equations.
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References
Noble, D., J. Physiol., 160, 317 (1962).
Schreiber, S. S., Amer. J. Physiol., 185, 337 (1956).
Brady, A. J., quoted in Brady, A. J., and Woodbury, J. W., J. Physiol., 154, 385 (1960).
Hodgkin, A. L., and Horowicz, P., J. Physiol., 148, 127 (1959).
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LAMB, J., MCGUIGAN, J. Potassium Fluxes in Quiescent and Beating Frog Ventricle. Nature 205, 1115–1116 (1965). https://doi.org/10.1038/2051115a0
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DOI: https://doi.org/10.1038/2051115a0
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