Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Infra-red Spectra and Chromatographic Fractions of Irradiated Linoleic and Linolenic Acids

Nature volume 205, pages 1106–1108 (1965)Cite this article

Abstract

A NUMBER of authors have suggested that cross-linking or related tanning interactions between lipid hydroperoxides and aortic wall proteins may be the ‘primary’ biochemical events in human atherogenesis1–4. Complexes do not seem to be formed, however, between mildly (thermally) oxidized corn oil or autoxidized linoleic acid preparations and either gelatine, lysine or glycine5, although stable hydroperoxides are probably formed under these and related experimental conditions6–8. In addition, synthetic hydroperoxides and peroxides (for example, tert.-butyl hydroperoxide, cumene hydroperoxide, para-methane hydroperoxide, diisopropylbenzene hydroperoxide and di-tert.-butyl peroxide and hydrogen peroxide) do not appear capable of acting as cross-linking agents for either native bovine aortae or chemically modified goatskin collagen preparations9.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Glavind, J., Hartmann, S., Clemmesen, J., Jessen, K. E., and Dam, H., Acta. Path. Microbiol. Scand., 30, 1 (1952).

    Article  CAS  Google Scholar 

  2. Harman, D., J. Gerontol., 12, 199 (1957).

    Article  CAS  Google Scholar 

  3. Nishida, T., Tsuchiyama, H., Inoue, M., and Kummerow, F. A., Proc. Soc. Exp. Biol. and Med., 105, 308 (1960).

    Article  CAS  Google Scholar 

  4. Nishida, T., and Kummerow, F. A., J. Lipid Res., 1, 450 (1960).

    CAS  PubMed  Google Scholar 

  5. Narayan, K. A., and Kummerow, F. A., J. Amer. Oil Chemists' Soc., 40, 339 (1963).

    Article  Google Scholar 

  6. Maier, V. P., and Tappel, A. L., J. Amer. Oil Chemists' Soc., 36, 12 (1959).

    Article  Google Scholar 

  7. Johnston, A. E., Zilch, K. T., Selke, E., and Dutton, H. J., J. Amer. Oil Chemists' Soc., 38, 367 (1961).

    Article  CAS  Google Scholar 

  8. Fraenkel, E. N., Evans, C. D., McConnell, D. G., Selke, E., and Dutton, H. J., J. Org. Chem., 26, 4663 (1961).

    Article  Google Scholar 

  9. Milch, R. A., J. Amer. Leather Chemists' Assoc., 57, 581 (1962); Gerontologia, 7, 129 (1963); Surgery, 54, 104 (1963); J. Atheroscl. Res. (in the press).

    CAS  Google Scholar 

  10. Knight, H. B., and Swern, D., J. Amer. Oil Chemists' Soc., 26, 366 (1949).

    Article  CAS  Google Scholar 

  11. Wilbur, K. M., Bernheim, F., and Shapiro, O. W., Arch. Biochem., 24, 305 (1949).

    CAS  PubMed  Google Scholar 

  12. Saslaw, L., Anderson, H. J., and Waravdekar, V. S., Nature, 200, 1098 (1963).

    Article  ADS  CAS  Google Scholar 

  13. Evans, T. C., and Feinstein, R. N. (eds.), Implications of Organic Peroxides in Radiobiology, Radiation Res. Suppl. 3 (1963).

  14. Gaddis, A. M., and Ellis, R., Science, 126, 745 (1957). Gaddis, A. M., Ellis, R., and Currie, G. T., Food Research, 25, 1 (1960); J. Food Sci., 26, 131 (1961); J. Amer. Oil Chemists' Soc., 38, 371 (1961).

    Article  ADS  CAS  Google Scholar 

  15. Younathan, M. T., and Watts, B. M., Food Research, 24, 728 (1959).

    Article  CAS  Google Scholar 

  16. Pippen, E. L., and Nonaka, M., Food Research, 25, 750 (1960).

    Article  Google Scholar 

  17. Brown, J. L., and Johnson, J. M., J. Lipid Res., 3, 480 (1962).

    CAS  Google Scholar 

  18. Boettcher, C. J. F., and Woodford, F. P., Fed. Proc., Suppl. II, Part II, 21, 15 (1962).

    Google Scholar 

  19. Karmen, A. (personal communication).

  20. Sinclair, R. G., McKay, A. F., Myers, G. S., and Jones, R. N., J. Amer. Chem. Soc., 74, 2578 (1952).

    Article  CAS  Google Scholar 

  21. Bellamy, L. J., The Infra-red Spectra of Complex Molecules, 2nd ed. (J. Wiley and Sons, Inc.: New York, 1958).

    Google Scholar 

  22. Susi, H., and Smith, A. M., J. Amer. Oil Chemists' Soc., 37, 431 (1960).

    Article  CAS  Google Scholar 

  23. Davison, W. H. T., J. Chem. Soc. (Lond.), 2456 (1951).

  24. Shreve, O. D., Heether, M. R., Knight, H. B., and Swern, D., Anal. Chem., 24, 638 (1952).

    Article  Google Scholar 

  25. Philpotts, A. R., and Thain, W., Anal. Chem., 24, 638 (1952).

    Article  CAS  Google Scholar 

  26. Minkoff, G. J., Proc. Roy. Soc., A, 224, 176 (1954).

    Article  ADS  CAS  Google Scholar 

  27. Williams, H. R., and Mosher, H. S., Anal. Chem., 27, 517 (1955).

    Article  CAS  Google Scholar 

  28. Farmer, E. H., Bloomfield, G. F., Sundralingam, A., and Sutton, D. A., Trans. Faraday Soc., 38, 348 (1942).

    Article  Google Scholar 

  29. Kawahara, F. J., and Dutton, H. J., J. Amer. Oil Chemists' Soc., 29, 372 (1952).

    Article  CAS  Google Scholar 

  30. Hoffman, G., J. Amer. Oil Chemists' Soc., 38, 1 (1961).

    Article  Google Scholar 

  31. Farriseey, jun., W. J., J. Org. Chem., 27, 3065 (1962).

    Article  Google Scholar 

  32. Gustavson, K. H., The Chemistry of Tanning Processes (Academic Press: New York, 1956).

    Google Scholar 

  33. Schultz, H. W., Day, E. A., and Sinnhuber, R. O. (eds.), Lipoids and their Oxidation (Avi Publ. Co.: Westport, Conn., 1962).

  34. Glavind, J., Søndergaard, E., and Dam, H., Acta Pharmacol. Toxicol., 18, 267 (1961).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery, and Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland

    ROBERT AUSTIN MILCH & GERALD A. KLASSEN

Authors
  1. ROBERT AUSTIN MILCH
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. GERALD A. KLASSEN
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

MILCH, R., KLASSEN, G. Infra-red Spectra and Chromatographic Fractions of Irradiated Linoleic and Linolenic Acids. Nature 205, 1106–1108 (1965). https://doi.org/10.1038/2051106a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/2051106a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing