Abstract
OUR interest in fluorine-containing α-amino-acids1–3 has led us to an investigation of the chemistry of β-pentafluorophenylalanine (I). We wish to report here the synthesis of this novel amino-acid by two different routes. (In a personal communication, Dr. P. L. Coe, University of Birmingham, England, has informed us that he has prepared compound I in impure form by means of the azlactone route. Preliminary tests with several micro-organisms indicated that the amino-acid was inactive.)
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FILLER, R., GUSTOWSKI, W. Synthesis of Pentafluorophenylalanine. Nature 205, 1105 (1965). https://doi.org/10.1038/2051105a0
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DOI: https://doi.org/10.1038/2051105a0
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