Abstract
THE protection afforded by infection with avirulent virus against subsequent challenge with a second lethal virus1 has led to the demonstration of interferon production by infected cells in vitro and in vivo2,3. Despite clinical evidence of the importance of bacterial interference, and experimental demonstration that avirulent staphylococci are capable of inhibiting nasal colonization with virulent staphylococci4, bacterial interference has not been extensively investigated in experimental models. Investigations of experimental staphylococcal infections in embryonated eggs have demonstrated that infection with strains of staphylococci that are not virulent for eggs affords significant protection against subsequent challenge with virulent staphylococci.
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References
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MCCARE, W. Staphylococcal Interference in Infections in Embryonated Eggs. Nature 205, 1023 (1965). https://doi.org/10.1038/2051023a0
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DOI: https://doi.org/10.1038/2051023a0
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