Abstract
ALTHOUGH the effects of pharmacological and biochemical substances on synaptic activation have been extensively investigated, the influence of pCO2 has received little or no attention1. It had been shown previously2 that large changes in pCO2 and pO2 altered synaptic activation, and the purpose of the present investigation was to examine quantitatively the effect of small changes in pCO2. Since the impaled mammalian neurone is extremely fragile, the first investigations, lasting for several hours, were performed on a sturdier preparation—the identifiable giant neurones of Aplysia fasciata.
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References
Eccles, J. C., Physiology of Synapses (Springer Verlag, Berlin, 1964).
Chalazonitis, N., Ann. N.Y. Acad. Sci., 109, 451, (1963).
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CHALAZONITIS, N., NAHAS, G. Small pCO2 Change and Neuronal Synaptic Activation. Nature 205, 1016–1017 (1965). https://doi.org/10.1038/2051016b0
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DOI: https://doi.org/10.1038/2051016b0
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