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Platelet Reaction to Adenosine Diphosphate in vivo

Nature volume 205, pages 91–92 (1965)Cite this article

Abstract

ADENOSINE diphosphate (ADP) causes agglutination of human1–3, cat4 and rabbit3,5 platelets in vitro and has also been shown to produce a rapid though transient fall in the number of circulating platelets when injected intravascularly4–6. Born and Cross4 postulated that the intravenous injection of the nucleotide led to a drop in the platelet count because “platelets adhere to endothelium and form aggregates which are trapped in the smallest vessels”. To test the hypothesis we observed platelet behaviour in small vessels following intravascular injection of ADP.

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References

  1. Gaarder, A., Jonsen, J., Laland, S., Hellem, A., and Owren, P. A., Nature, 192, 531 (1961).

    Article  ADS  CAS  Google Scholar 

  2. Born, G. V. R., Nature, 194, 927 (1962).

    Article  ADS  CAS  Google Scholar 

  3. Mitchell, J. R. A., and Sharp, A. A., Brit. J. Hæmat., 10, 78 (1964).

    Article  CAS  Google Scholar 

  4. Born, G. V. R., and Cross, M. J., Nature, 197, 974 (1963).

    Article  ADS  CAS  Google Scholar 

  5. Regoli, D., and Clark, V., Nature, 200, 546 (1963).

    Article  ADS  CAS  Google Scholar 

  6. Davey, M. G., and Lander, H., Nature, 201, 1037 (1964).

    Article  ADS  CAS  Google Scholar 

  7. Ebert, R. H., Florey, H. W., and Pullinger, B. D., J. Path. Bact., 48, 79 (1989).

    Article  Google Scholar 

  8. Sanders, A. G., Ebert, R. H., and Florey, H. W., Quart. J. Exp. Physiol., 30, 281 (1940).

    Article  Google Scholar 

  9. Brecher, G., and Oonkite, E. P., J. App. Physiol, 3, 365 (1950).

    Article  CAS  Google Scholar 

  10. Stehbens, W. E., and Florey, H. W., Quart. J. Exp. Physiol., 45, 252 (1960).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Experimental Pathology, John Curtin School of Medical Research, Australian National University, Canberra, Australia

    M. D. SILVER & W. E. STEHBENS

  2. Commonwealth Health Laboratory, Canberra, Australia

    MEREDITH M. SILVER

Authors
  1. M. D. SILVER
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  2. W. E. STEHBENS
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  3. MEREDITH M. SILVER
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SILVER, M., STEHBENS, W. & SILVER, M. Platelet Reaction to Adenosine Diphosphate in vivo. Nature 205, 91–92 (1965). https://doi.org/10.1038/205091a0

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