Abstract
IT has recently been shown that inoculation of mice and hamsters with several oncogenic viruses (polyoma, SV 40, myeloid and lymphoid mouse leukæmia) makes them resistant to subsequent transplantation of tumour cells induced by the same virus. Our observations on chickens naturally resistant to the Rous sarcoma virus, or chickens with regressed tumours, suggested that in some instances it was possible to induce resistance to Rous sarcoma cell antigens in chickens. If this were true then the Rous sarcoma is not basically different from the polyoma and other virus tumours. However, certain characteristics of the processes induced by Rous virus (the susceptibility of the adult chicken to this virus, the permanent presence of the virus in tumour cells, the short latent period of tumour induction) make it very difficult to investigate resistance to this tumour cell antigen in its natural host—the chicken. Therefore, it was interesting to investigate the possibility of inducing resistance to the Rous sarcoma cells in a mammal.
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RADZICHOVSKAJA, R. Observations on Induction of Resistance to Rous Sarcoma Cell Antigens in Hamsters. Nature 204, 393 (1964). https://doi.org/10.1038/204393a0
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DOI: https://doi.org/10.1038/204393a0
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