Abstract
PREVIOUS work carried out in this Laboratory was devoted to explaining the effective physiological role of ornithine cycle reactions in urea biosynthesis1,2. On the basis of the results obtained, serious doubts arose concerning the role of argininosuccinate synthetase in this process as well as with regard to the position of carbamylphosphate as an intermediate in nitrogen transfer from protein to urea. So far as the problem of urea biosynthesis is concerned, we are now investigating the role of arginase in this process. This communication reports in vivo inhibition of rat liver arginase activity by a strong competitive arginase inhibitor, L-lysine3,4.
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CITTADINI, D., PIETROPAOLO, C., DE CRISTOFARO, D. et al. In vivo Effect of L-Lysine on Rat Liver Arginase. Nature 203, 643–644 (1964). https://doi.org/10.1038/203643a0
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DOI: https://doi.org/10.1038/203643a0
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