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Resistance against Carcinomas of the Skin induced by Dimethylbenzanthracene (DMBA) in Mice of the Strain XVII/Bln

Abstract

PAST investigations in many laboratories concerning the antigenicity of experimental tumours have revealed that almost all the sarcomas induced by carcinogenic hydrocarbons contain specific antigens. For this reason a certain pretreatment of isologous recipients with these tumours can produce resistance against cell inocula of the tumour originally taken for immunization. Using this test system specific antigens were demonstrated in sarcomas which were induced by administration of methylcholanthrene1–7, benzpyrene5,8,9, dibenzpyrene6, dibenzanthracene10, and dimethylbenzanthracene11.

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References

  1. Foley, E. J., Cancer Res., 13, 835 (1953).

    CAS  PubMed  Google Scholar 

  2. Prehn, R. T., and Main, J. M., J. Nat. Cancer Inst., 18, 769 (1957).

    CAS  PubMed  Google Scholar 

  3. Révész, L., Cancer Res., 20, 443 (1960).

    Google Scholar 

  4. Klein, G., Sjögren, H. O., Klein, E., and Hellström, K. E., Cancer Res., 20, 1561 (1960).

    CAS  PubMed  Google Scholar 

  5. Koldovský, P., Folia biol., 7, 115 (1961).

    Google Scholar 

  6. Old, L. J., Benacerraf, B., Clarke, D. A., Carswell, E. A., and Stockert, E., Cancer Res., 21, 1281 (1961).

    CAS  PubMed  Google Scholar 

  7. Pasternak, G., Graffi, A., and Horn, K.-H., Acta biol. med. germ., 9, 302 (1962).

    CAS  PubMed  Google Scholar 

  8. Graffi, A., Pasternak, G., and Horn, K.-H., Acta biol. med. germ., 9, 318 (1962).

    CAS  PubMed  Google Scholar 

  9. Feldman, M., Globerson, A., and Yaffe, D., Acta Unio Contra Cancr., 19, 65 (1963).

    CAS  Google Scholar 

  10. Prehn, R. T., Cancer Res., 20, 1614 (1960).

    CAS  Google Scholar 

  11. Pasternak, G., Acta biol. med. germ., 10, 572 (1963).

    CAS  PubMed  Google Scholar 

  12. Prehn, R. T., Ann. N.Y. Acad. Sci., 101, 107 (1962).

    Article  ADS  CAS  Google Scholar 

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PASTERNAK, G., GRAFFI, A., HOFFMANN, F. et al. Resistance against Carcinomas of the Skin induced by Dimethylbenzanthracene (DMBA) in Mice of the Strain XVII/Bln. Nature 203, 307–308 (1964). https://doi.org/10.1038/203307b0

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