Abstract
NICKEL and nickel compounds, notably nickel sulphide, are potent local acting carcinogens when administered parenterally to laboratory rats1,2. The tumour arising from exposure of muscle tissue to powdered nickel sulphide is almost invariably a pleomorphic rhabdomyosarcoma ; a fact suggesting a high tissue specificity for this metal2. Disks of nickel sulphide implanted in the hip muscles of laboratory rats had essentially the same tumorigenic effect as did the implantation of chips or powder3. Comparable results were also obtained when 5-µ, particles of nickel sulphide were implanted in ‘Millipore’ diffusion chambers of 0.45µ porosity3. This communication is concerned with establishing the approximate exposure time necessary for nickel sulphide to bring about malignant change in muscle tissue.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Hueper, W. C., J. Nat. Cancer Inst., 16, 55 (1955).
Gilman, J. P. W., Cancer Res., 22, 158 (1962).
Gilman, J. P. W., and Herchen, H., Acta Unio Intern. Contra Cancrum, 19, 615 (1963).
Herchen, H., M.V.Sc. thesis, Univ. Toronto (1962).
Oppenheimer, B. S., Oppenheimer, E. T., Stout, A. P., Wilhite, M., and Danishefsky, I., Cancer, 11, 204 (1958).
Laird, A. K., and Barton, A. D., Amer. J. Path., 12, 2 (1959).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HERCHEN, H., GILMAN, J. Effect of Duration of Exposure on Nickel Sulphide Tumorigenesis. Nature 202, 306–307 (1964). https://doi.org/10.1038/202306a0
Issue Date:
DOI: https://doi.org/10.1038/202306a0
This article is cited by
-
Acid phosphatase and succinate and dehydroorotate dehydrogenase activity during interaction between allogeneic lymphocytes and target cells in tissue culture
Bulletin of Experimental Biology and Medicine (1975)
-
Interferon and the Interaction of Allogeneic Normal and Immune Lymphocytes with L-cells
Nature (1967)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
