Abstract
J. F. A. P. MILLER has described1 the role of thymus in the development of a normal immune system. J. F. A. P. Miller and his colleagues have shown also the influence of thymectomy on the induction of 3,4-benzpyrene skin cancer in mice2. Moreover, I have shown that homograft of neonatal thymus has an inhibiting influence on the incidence of 20-methylcholanthrene (MC) skin cancer in mice of the L strain3. In these experiments the differences in incidence of induced cancer up to the 120 days after the beginning of the experiment between the control group of animals and the animals repeatedly grafted of neonatal thymus during the whole course of the experiment were significant.
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Miller, J. F. A. P., Lancet, ii, 748 (1961); Ciba Symp. Transplantation, 384 (1962). Miller, J. F. A. P., et al., Adv. in Immunology, 2, 3 (Academic Press, 1962).
Miller, J., Grant, G. A., and Roe, F. J. C., Nature, 199, 920 (1963).
Maisin, J. H. F., C.R. Soc. Biol., 152, 1519 (1963).
Osoba, D., and Miller, J. F. A. P., Nature, 199, 653 (1963). Levey, R. H., Trainin, N., and Law, L. W., J. Nat. Cancer Inst., 31, 199 (1963).
Szent-Györgyi, A., Hegyell, A., and McLaughlin, J. A., Proc. U.S. Nat. Acad. Sci., 48, 1439 (1962); 49, 230 (1963).
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MAISIN, J. Role of Thymus and Thymus Factors in the Induction of 20-Methylcholanthrene : Skin Cancer in Mice. Nature 202, 202 (1964). https://doi.org/10.1038/202202a0
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DOI: https://doi.org/10.1038/202202a0
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