Abstract
WHEN tritium is introduced into (−)-inositol (I) by the Wilzbach method1—exposure to tritium gas for a prolonged period—considerable inversion occurs and tritium-labelled myoinositol (II) is one of the products2,3. It has been assumed3 that the myoinositol must be specifically labelled on C1 only since inversion occurs during the replacement of hydrogen by tritium. This assumption has now been shown, by degradation of the myoinositol, to be correct.
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References
Wilzbach, K. E., J. Amer. Chem. Soc., 79, 1013 (1957).
Angyal, S. J., Garnett, J. L., and Hoskinson, R. M., Nature, 197, 485 (1963).
Angyal, S. J., Garnett, J. L., and Hoskinson, R. M., Austral. J. Chem., 16, 252 (1963).
Angyal, S. J., Tate, M. E., and Gero, S. D., J. Chem. Soc., 4116 (1961).
Angyal, S. J., and Gero, S. D. (unpublished results.)
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ANGYAL, S., FERNANDEZ, C. Specific Tritium Labelling by the Wilzbach Method. Nature 202, 176–177 (1964). https://doi.org/10.1038/202176a0
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DOI: https://doi.org/10.1038/202176a0
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